https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52918 Wed 01 Nov 2023 09:31:20 AEDT ]]> TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54960 Fri 22 Mar 2024 15:34:43 AEDT ]]> Variants associated with HHIP expression have sexdifferential effects on lung function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41061 HHIP) gene and was previously associated with lung function and HHIP lung expression. We found HHIP expression was significantly different between the sexes (P=6.90x10⁻⁶), but we could not detect sex differential effects of rs7697189 on expression. Conclusions: We identified a novel genotype-by-sex interaction at a putative enhancer region upstream of the HHIP gene. Establishing the mechanism by which HHIP SNPs have different effects on lung function in males and females will be important for our understanding of lung health and diseases in both sexes.]]> Fri 22 Jul 2022 13:18:47 AEST ]]>